Cristina Sottani, Benedetta Porro, Marcello Imbriani, Claudio Minoia.
Exposure assessment of health care workers to antineoplastic drugs (ADs) is still an open issue since new, critical, and emerging factors may put pharmacists who prepare hazardous drugs or nurses who administer anti cancer agents to an increased risk of developing adverse health effects.
Milena Villarini, Luca Dominici, Renza Piccinini, Cristina Fatigoni, Maura Ambrogi, Gianluca Curti, Piero Morucci, Giacomo Muzi, Silvano Monarca, Massimo Moretti.
The International Agency for Research on Cancer has classified several antineoplastic drugs in Group 1 (human carcinogens), among which chlorambucil, cyclophosphamide (CP) and tamoxifen, Group 2A (probable human carcinogens), among which cisplatin, etoposide, N-ethyland N-methyl-N-nitrosourea, and Group 2B (possible human carcinogens), among which bleomycins, merphalan and mitomycin C.
Pamela A Ratner, John J Spinelli, Kris Beking, Maria Lorenzi, Yat Chow, Kay Teschke, Nhu D Le, Richard P Gallagher, Helen Dimich-Ward.
Background: To determine the relationships of potential occupational exposure to antineoplastic drugs with cancer incidence and adverse pregnancy outcomes in a historical prospective cohort study of female registered nurses (RNs) from British Columbia, Canada (BC).
Martha Polovichand, Patricia C. Clark.
Problem: Nurses are potentially exposed to hazardous drugs (HDs) in their practice.
HD exposure is associated with adverse outcomes (reproductive problems, learning disabilities in offspring of nurses exposed during pregnancy, and cancer occurrence). Safe handling precautions (safety equipment and personal protective equipment, [PPE]) minimize exposure to HDs and decrease the potential for adverse outcomes.
Wouter Fransman, Susan Peelen Simone Hilhorst, Nel Roeleveld, Dick Heederik and Hans Kromhout.
The purpose of the study was to evaluate the frequency of spontaneous abortion in two groups of women. One group consisted of women regularly involved in the preparation of cancer chemothe rapy perfusions and therefore considered to be exposed to cytostatic agents; the other consisted of women not occupationally exposed to such agents. The study was carried out in four French hospitals.
Paul J.M. Sessink and Rob P. Bos.
We review the literature concerning possible health risks for individuals (e.g. healthcare workers and pharmaceutical plant employees) occupationally exposed to cytostatic drugs. Cytostatic drugs possess toxic properties and may therefore cause mutagenic, carcinogenic and teratogenic effects. Hence, individuals handling these drugs in the course of their employment may face health risks. For this reason, it is important to monitor occupational exposure to these drugs.
Torsten Skov, Birgit Maarup, Jorn Olsen, Mikael Rorth, Hanna Winthereik, Elsebeth Lynge.
During the past decades conclusive evidence has accumulated that alkylating antineoplastic drugs (ADs) can cause cancer, most notably acute non-lymphocytic leukaemia, and that most ADs are reprotoxic. Studies on health workers handling ADs have shown significantly increased risks for miscarriages (two studies) and malformations (two studies).
Isabelle Stucker, PhD, Jean-Francois Caillard, MD, Renee Collin , MD, Michele Gout, MD, Daniele Poyen, MD, Denis Heman, PhD.
The purpose of the study was to evaluate the frequency of spontaneous abortion in two groups of women.
Torsten Skov, Birgit Maarup, Jorn Olsen, Mikael Rorth, Hanna Winthereik, Elsebeth Lynge Abstract: In a case-control study, we examined the relation between fetal loss and occupational exposure to antineoplastic drugs in nurses in 17 Finnish hospitals.The...